QUPIC
QUPIC (PB-22 or 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) is a designer drug offered by online vendors as a cannabimimetic agent, and detected being sold in Synthetic Cannabis products in Japan in 2013.The structure of QUPIC appears to use an understanding of structure-activity relationships within the indole class of cannabimimetics, although its design origins are unclear. QUPIC represents a structurally unique synthetic cannabinoid chemotype, since it contains an ester linker at the indole 3-position, rather than the precedented ketone of JWH-018 and its analogs, or the amide of SDB-001 and its analogs. No information regarding the in vitro activity of QUPIC has been published, however one in vivo study found PB-22 to cause seizures in humans and dogs. QUPIC is an analog of JWH-018 which differs by having 8-hydroxyquinoline replacing the naphthalene group of JWH-018. QUPIC is now found in many herbal incense and potpourri products.
Detection
A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website of potential drugs of abuse.
Legal status
As of 9 May 2014, PB-22 is no longer legal in New Zealand.
In January 2014, QUPIC was designated as a Schedule I controlled substance in the United States.
In Ohio, QUPIC is illegal.
Florida also has banned QUPIC/P-22.
Since 13.Dezember 2014 it is also illegal in Germany because of adding the substance to the BtMG Anlage II.
