Difference between revisions of "AM-694"
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Latest revision as of 16:30, 14 February 2015
AM-694 (1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole) is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB1. It is used in scientific research for mapping the distribution of CB1 receptors. No public data about AM-694 metabolism is known. AM-694 has already emerged as a designer drug.
Pharmacology
AM-694 is an agonist for cannabinoid receptors. Affinities are: with a Ki of 0.08nM at CB1 and 18x selectivity over CB2 with a Ki 1.44nM. It is unclear what is responsible for this unusually high CB1 binding affinity, but it makes the 18F radiolabelled derivative of AM-694 useful for mapping the distribution of CB1 receptors in the body.
Pharmacokinetics
AM-694 metabolism differs only slightly from that of JWH-018. AM-694 N-dealkylation produces fluoropentane instead of pentane (or plain alkanes in general). It has been speculated that the fluoropentane might function as an alkylating agent or is further metabolized into toxic fluoroacetic acid. This is not true since fluoroalkanes do not act as alkylating agents under normal conditions and uneven fluoroalkane chains metabolize into substantially less toxic fluoropropanoic acid.
