Difference between revisions of "JWH-098"
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| − | JWH-098 is a synthetic [[cannabinoid receptor]] | + | JWH-098 is a synthetic [[cannabinoid receptor agonist]] from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound [[JWH-081]], but has markedly different affinity for the [[CB1]] and [[CB2 receptor]]s. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use. |
==See also== | ==See also== | ||
Revision as of 06:03, 16 February 2015
JWH-098 is a synthetic cannabinoid receptor agonist from the naphthoylindole family. It is the indole 2-methyl derivative of a closely related compound JWH-081, but has markedly different affinity for the CB1 and CB2 receptors. While JWH-081 is around 10x selective for CB1 over CB2, in JWH-098 this is reversed, and it is around 4 times weaker than JWH-081 at CB1 while being six times more potent at CB2, giving it a slight selectivity for CB2 overall. This makes JWH-098 a good example of how methylation of the indole 2-position in the naphthoylindole series tends to increase CB2 affinity, but often at the expense of CB1 binding. JWH-098 is illegal in Russia, Sweden, and the UK, although it is unclear whether it has any history of human use.
