Difference between revisions of "O-2694"
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| − | O-2694 is a drug that is a [[cannabinoid]] derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[CB1]] and [[CB2 | + | O-2694 is a drug that is a [[cannabinoid]] derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both [[CB1]] and [[CB2 receptor]]s, with Ki values of 3.7nM at CB1 and 2.8nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound [[O-2372]], thus producing a biphasic effects profile that is less suitable for research purposes than the related compound [[O-2545]]. |
==See also== | ==See also== | ||
Latest revision as of 01:56, 15 February 2015
O-2694 is a drug that is a cannabinoid derivative. It has analgesic effects and is used in scientific research. Unlike most cannabinoids discovered to date, it is highly water-soluble, which gives it considerable advantages over many related drugs. It has high affinity for both CB1 and CB2 receptors, with Ki values of 3.7nM at CB1 and 2.8nM at CB2. However, it has complex pharmacokinetics as most of the administered dose is metabolised by hydrolysis of the ester link to the water-insoluble compound O-2372, thus producing a biphasic effects profile that is less suitable for research purposes than the related compound O-2545.
