Tetrahydrocannabinol - Revision history

JChidiac: /* Medical Uses */

2015-05-06T18:33:14Z

‎Medical Uses

Adm1n at 17:11, 3 February 2015

2015-02-03T17:11:35Z

Adm1n at 16:50, 3 February 2015

2015-02-03T16:50:00Z

Adm1n at 16:49, 3 February 2015

2015-02-03T16:49:40Z

Adm1n at 21:59, 26 January 2015

2015-01-26T21:59:43Z

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Adm1n at 21:57, 26 January 2015

2015-01-26T21:57:36Z

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Adm1n: Created page with "Tetrahydrocannabinol (THC), or more precisely its main isomer (-)-trans-?9-tetrahydrocannabinol (?(6aR,10aR)-delta-9-tetrahydrocannabinol), is the principal psychoactive c..."

2015-01-22T06:28:15Z

Created page with "Tetrahydrocannabinol (THC), or more precisely its main isomer (-)-trans-?9-tetrahydrocannabinol (?(6aR,10aR)-delta-9-tetrahydrocannabinol), is the principal psychoactive c..."

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Tetrahydrocannabinol ([[THC]]), or more precisely its main isomer (-)-trans-?9-tetrahydrocannabinol (?(6aR,10aR)-delta-9-tetrahydrocannabinol), is the principal psychoactive constituent (or [[cannabinoid]]) of the [[Cannabis]] plant. First isolated in 1964 by Israeli scientists Raphael Mechoulam and Yechiel Gaoni at the Weizmann Institute of Science[10] it is a water-clear glassy solid when cold, which becomes viscous and sticky if warmed. A pharmaceutical formulation of (-)-trans-?9-tetrahydrocannabinol, known by its INN dronabinol, is available by prescription in the U.S. and Canada under the brand name Marinol. An aromatic terpenoid, THC has a very low solubility in water, but good solubility in most organic solvents, specifically lipids and alcohols. [[THC]], [[CBD]], [[CBN]], [[CBC]], [[CBG]] and about 80 other molecules make up the [[phytocannabinoid]] family.

Like most pharmacologically-active secondary metabolites of plants, THC in cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.
Tetrahydrocannabinol, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).

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 == Medical Uses ==
 In April 2014 the American Academy of Neurology published a systematic review of the efficacy and safety of medical marijuana and marijuana-derived products in certain neurological disorders. The review identified 34 studies meeting inclusion criteria, of which 8 were rated as Class I quality. The study found evidence supporting the effectiveness of cannabis extracts and THC in treating certain symptoms of multiple sclerosis, but found insufficient evidence to determine the effectiveness of cannabis products in treating several other neurological diseases.
 '''Multiple sclerosis symptoms'''
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 Centrally mediated pain and painful spasms. Based on the results of 4 high quality trials and 4 low quality trials, oral cannabis extract was rated as effective, and THC as probably effective in treating central pain and painful spasms.
 Bladder dysfunction. Based on a single high quality study, oral cannabis extract and THC were rated as probably ineffective for controlling bladder complaints in multiple sclerosis
 '''Neurodegenerative disorders'''
-Huntington disease. No reliable conclusions could be drawn regarding the effectiveness of THC or oral cannabis extract in treating the symptoms of Huntington disease as the available trials were too small to reliably detect any difference
+THC has been shown to have neuroprotective actions against injury or damage from autoimmune disorders [http://www.ncbi.nlm.nih.gov/pubmed/25537576].
 Parkinson disease. Based on a single study, oral cannabis extract was rated probably ineffective in treating levodopa-induced dyskinesia in Parkinson disease.
 Alzheimer's disease. A 2011 Cochrane Review found insufficient evidence to conclude whether cannabis products have any utility in the treatment of Alzheimer's disease.

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 Like most pharmacologically-active secondary metabolites of plants, THC in cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.
 Tetrahydrocannabinol, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).
-[[File:thc.png|200px|thumb|right|Chemistry of THC]]
+[[File:thc.png|300px|thumb|right|Chemistry of THC]]

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 Like most pharmacologically-active secondary metabolites of plants, THC in cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.
 Tetrahydrocannabinol, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).
-[[File:thc.png|200px|thumb|left|Chemistry of THC]]
+[[File:thc.png|200px|thumb|right|Chemistry of THC]]

← Older revision		Revision as of 16:49, 3 February 2015
Line 3:		Line 3:
	Like most pharmacologically-active secondary metabolites of plants, THC in cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.		Like most pharmacologically-active secondary metabolites of plants, THC in cannabis is assumed to be involved in self-defense, perhaps against herbivores. THC also possesses high UV-B (280–315 nm) absorption properties, which, it has been speculated, could protect the plant from harmful UV radiation exposure.
	Tetrahydrocannabinol, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).		Tetrahydrocannabinol, along with its double bond isomers and their stereoisomers, is one of only three cannabinoids scheduled by the Convention on Psychotropic Substances (the other two are dimethylheptylpyran and parahexyl). Cannabis as a plant is scheduled by the Single Convention on Narcotic Drugs (Schedule I and IV).
		+	[[File:thc.png\|200px\|thumb\|left\|Chemistry of THC]]