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HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Professor Raphael Mechoulam at the Hebrew University. HU-210 is 100 to 800 times more potent than natural THC from cannabis and has an extended duration of action. HU-210 is the (–)-1,1-dimethylheptyl analog of 11-hydroxy- Δ8- [[tetrahydrocannabinol]]; in some references it is called 1,1-dimethylheptyl- 11-hydroxytetrahydrocannabinol. The abbreviation "HU" stands for Hebrew University.

The (+) enantiomer of HU-210 has almost all of the cannabinoid activity, with the (−) enantiomer HU-211 being inactive as a cannabinoid but instead acting as an NMDA antagonist having neuroprotective effects.

HU-210 promotes proliferation, but not differentiation, of cultured embryonic hippocampal neural stem and progenitor cells likely via a sequential activation of [[CB1]] receptors, Gi/o proteins, and ERK signaling. It was also indicated by this increased neural growth to entail antianxiety and antidepressant effects.

HU-210, alongside other synthetic cannabinoids like WIN 55,212-2 and JWH-133, is implicated in preventing the inflammation caused by amyloid beta proteins involved in Alzheimer's disease, in addition to preventing cognitive impairment and loss of neuronal markers. This anti-inflammatory action is induced through the activation of [[cannabinoid receptors]], which prevents microglial activation that elicits the inflammation. In addition, cannabinoids completely abolish neurotoxicity related to microglia activation in rat models.

HU-210 is a potent analgesic with many of the same effects as natural [[THC]].

== Recreational use ==

According to the U.S. Customs and Border Protection, HU-210 was discovered in Spice Gold incense products seized at the US border in January 2009. Over 100 pounds of Spice products were seized based on this finding. HU-210 was also detected in three Spice products in the UK, as reported in June 2009.

== Legal status ==

'''United States'''

HU-210 is a schedule I controlled substance under the Controlled Substances Act.

To view national schedule, see: List of Schedule I drugs (US),

'''New Zealand'''

Banned in New Zealand as of 8 May 2014.

== Other HU Cannabinoids ==

*[[HU-211]]

*[[HU-239]]

*[[HU-243]]

*[[HU-308]]

*[[HU-320]]

*[[HU-331]]

*[[HU-336]]

*[[HU-345]]

== See also ==

*[[CP 47,497]]

*[[JWH-018]]

HU-210 - Revision history

Adm1n: Created page with "HU-210 is a synthetic cannabinoid that was first synthesized in 1988 from (1R,5S)-myrtenol by a group led by Professor Raphael Mechoulam at the Hebrew University. HU-210 is 10..."