Adm1n: Created page with "GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity o..."

2015-02-16T14:37:28Z

Created page with "GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity o..."

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GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the [[cannabinoid receptor]] subtype[[ CB2]], with an EC50 of 0.65nM and selectivity of around 1200x for CB2 over [[CB1]] receptors. Animal studies have shown it to possess antiinflammatory and anti-hyperalgesic effects at low doses, followed by ataxia and analgesic effects when the dose is increased. Selective CB2 agonist drugs such as GW-405,833 are hoped to be particularly useful in the treatment of allodynia and neuropathic pain for which current treatment options are often inadequate.

GW-405,833 - Revision history

Adm1n: Created page with "GW-405,833 (L-768,242) is a drug that acts as a potent and selective partial agonist for the cannabinoid receptor subtype CB2, with an EC50 of 0.65nM and selectivity o..."