Adm1n at 14:38, 14 February 2015

2015-02-14T14:38:41Z

Adm1n: Created page with "AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency..."

2015-02-14T14:38:25Z

Created page with "AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency..."

New page

AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors [[CB1]] and [[CB2]], but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived [[cannabinoid]] ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position. The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another [[synthetic cannabinoid]] [[AM-679]].

==See also==

* [[A-834,735]]
* [[AB-001]]
* [[AM-411]]
* [[AM-1220]]
* [[AM-2233]]
* [[Cannabipiperidiethanone]]

← Older revision		Revision as of 14:38, 14 February 2015
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−	AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors [[CB1]] and [[CB2]], but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived [[cannabinoid]] ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position. The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another [[synthetic cannabinoid]] [[AM-679]].	+	AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors [[CB1]] and [[CB2]], but with some dispute between sources over its exact potency and selectivity. Replacing the 3-(1-naphthoyl) group found in many indole derived [[cannabinoid]] ligands, with an adamantoyl group, generally confers significant CB2 selectivity, but reasonable CB1 affinity and selectivity is retained when an N-methylpiperidin-2-ylmethyl substitution is used at the indole 1-position. The related compound 1-pentyl-3-(1-adamantoyl)indole was identified as having been sold as a cannabinoid designer drug in Hungary in 2011, along with another synthetic cannabinoid [[AM-679]].

AM-1248 - Revision history

Adm1n at 14:38, 14 February 2015

Adm1n: Created page with "AM-1248 is a drug that acts as a moderately potent agonist for both the cannabinoid receptors CB1 and CB2, but with some dispute between sources over its exact potency..."