Adm1n: Created page with "AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor, giving it ar..."

2015-02-14T14:22:31Z

Created page with "AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor, giving it ar..."

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AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor [[CB2]], with a Ki of 0.28nM at CB2 and 52.3nM at the [[CB1]] receptor, giving it around 180x selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a truly selective CB2 agonist, so the related compound [[AM-1241]] is generally preferred for research purposes.

==See also==

* [[AM-630]]
* [[AM-1220]]
* [[AM-1235]]
* [[AM-2233]]
* [[UR-144]]
* [[N-(S)-Fenchyl-1-(2-morpholinoethyl)-7-methoxyindole-3-carboxamide]]

AM-1221 - Revision history

Adm1n: Created page with "AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28nM at CB2 and 52.3nM at the CB1 receptor, giving it ar..."